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      <h1>TFIS v1.0</h1>
      <p>Transcription Factor Information System</p>
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      <h2>About TFIS v1.0</h2>
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Transcription Factor Information System (v1.0) is an online tool having a collection of JAVA programs. Each JAVA program is coded to provide unique valuable information about Transcription Factors and their binding sites. Transcription Factors are proteins those bind to DNA at specific sites (Transcription Factor Binding Sites) and control the gene expression. Hence this tool is developed to identify these TFBSs in DNA so that the mechanism that regulate gene expression can be understood in a better way.
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        <p> Transcription Factors are proteins those bind to DNA at specific sites (Transcription Factor Binding Sites or TFBSs) and control the gene expression. Hence identifying these TFBSs in DNA is important to understand the mechanism that regulates gene expression. For efficient understanding of these mechanisms there is a need to develop new computational tools for detecting these TFBSs, having more efficiency and advanced options so that detailed hence better results can be obtained. These tools must be developed as web applications so that user can easily access the capabilities online. These tools must also have user friendly interface so that a person with biology background can understand the functioning and result output easily. For this purpose TFIS v1.0 is developed which is an online computational tool for detecting potential TFBS. TFIS v1.0 is a collection of JAVA programs and is mainly based on TFBS detection using PWM. The database used for obtaining PFM is JASPAR which is an open access database of transcription factor binding profiles. The tool uses pseudocounts while converting PFM to PWM and TFBS detection is carried out on the basis of percent score taken as threshold value. This tool is developed in JAVA language using NetBeans IDE and is deployed to Google App Engine using Eclipse IDE. TFIS v1.0 is equipped with advanced features such as direct information fetching from NCBI database, detecting binding site for common TF in a batch of gene sequences and TFBS detection after generating PWM from raw sequences in addition to general detection methods. This tool supports the use of JAVA language as an advanced bioinformatics programming language. This tool can be publicly accessed at http://www.tfis.in.  This tool is surely an advanced tool as it is able to provide solutions which are not present in any other tool for example, TFSEARCH tool has a limit of up to 9,999 bases for gene sequence input while TFIS v1.0 is free of such limitation.
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   <div id="footer">Sengupta <i>et al.</i> | Developed and Maintained by <a href="http://www.abhishekduhoon.com" target="_blank">Abhishek Kumar</a>.
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